Mr HF has been treated for HIV for the last 10 years and his viral load has been successfully suppressed during his treatment. He is currently taking:
- Zidovudine/Lamivudine 300 mg/150 mg bd
- Nevirapine (XR) 400 mg d
- Rosiglitazone/Metformin 2mg/500mg bd
- Ramipril 10 mg d
He is admitted to hospital with pneumonia. The causative agent was identified as Pneumocystis jiroveci. Treatment was initiated with pentamide as he was allergic to sulphamethoxazole but he failed to respond to treatment. When antibiotic sensitive results came back it was found to be only sensitive to sulphamethoxazole & trimethoprim. As the pharmacist serving the local hospital your expertise is called upon.
Discuss the issues of the pharmacological management of this case? (Max: 600 words)